Liquid Chromatography Mass Spectrometry (LC-MS)

Liquid Chromatography-Mass Spectrometry (LC-MS) is a powerful analytical technique used in chemistry and biology. LC separates complex mixtures of compounds, and MS identifies and quantifies them. In LC, a liquid mobile phase carries the sample through a column, separating components based on their chemical properties. The eluent then enters the MS, where ions are generated, and their mass-to-charge ratios are measured. By comparing mass spectra with known standards, LC-MS identifies compounds with high sensitivity and specificity. It is widely applied in drug discovery, environmental analysis, and metabolomics, providing invaluable insights into complex mixtures.